Expression ofZNF804Ain Human Brain and Alterations in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
نویسندگان
چکیده
منابع مشابه
Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
BACKGROUND Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA...
متن کاملBrain Circuits in Major Depressive Disorder and Bipolar Disorder
The lifetime prevalence rates of unipolar depression (UPD) in males and females of first-world countries are approximately 15 and 25 percent, respectively. The figures appear to be equally disheartening in developing countries: The 12-month prevalence of major depressive disorder in South Africa is roughly 5 percent. It is therefore not surprising that 25 percent of all visits to health care pr...
متن کاملDisease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium.
Severe psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder are brain diseases of unknown origin. No biological marker has been documented at the pathological, cellular, or molecular level, suggesting that a number of complex but subtle changes underlie these illnesses. We have used proteomic technology to survey postmortem tissue to identify changes linke...
متن کاملExpression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.
IMPORTANCE The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. OBJECTIVES To characterize ZNF804A expression in human brain and to investigate how it changes across the life span and how it is aff...
متن کاملComparison of depressive episodes in bipolar disorder and in major depressive disorder within bipolar disorder pedigrees.
BACKGROUND Although genetic epidemiological studies have confirmed increased rates of major depressive disorder among the relatives of people with bipolar affective disorder, no report has compared the clinical characteristics of depression between these two groups. AIMS To compare clinical features of depressive episodes across participants with major depressive disorder and bipolar disorder...
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ژورنال
عنوان ژورنال: JAMA Psychiatry
سال: 2014
ISSN: 2168-622X
DOI: 10.1001/jamapsychiatry.2014.1079